What is the difference between polymerase 1 2 and 3

A Replisome is located at the replication fork. DNA polymerase 3 is a component of the replisome and hence helps in replication. DNA polymerase 3 is essential for the replication of the leading and the lagging strands whereas DNA polymerase 1 is essential for removing of the RNA primers from the fragments and replacing it with the required nucleotides. These enzymes cannot replace each other as both have different functions to be performed. DNA polymerases help in transferring the genetic information and the traits from one generation to another through the process of DNA replication.

Difference between DNA polymerase 1 and 3. Difference Between Similar Terms and Objects. MLA 8 P, Rachita. Name required. Email required. Please note: comment moderation is enabled and may delay your comment. There is no need to resubmit your comment. The Klenow fragment is a useful molecule in DNA amplification reactions. This is important in mismatch repair. The three functional domains of DNA polymerase 1 is shown in figure 1.

The enzyme aids the base pairing of incoming nucleotides with the template strand. Hence, this enzyme reads the just added nucleotides, and if there is any mismatch with the template strand, it will be removed and resynthesized. Therefore, DNA polymerase 3 is important in maintaining the stability of the genome. Figure 2: DNA polymerase 3. DNA polymerase 3 holoenzymes is composed of ten subunits, which are arranged into two DNA polymerases.

DNA polymerase is an important enzyme class found in all living organisms. This enzyme exists in different forms varying from shape and size. Pol 1 catalyzes the repairing of DNA damages. Pol 2 catalyzes the fidelity and processivity of DNA replication. Reference: 1. Lehman, I.

Gardner, Andrew F. Frontiers, 13 Nov. Garcia-Diaz, Miguel, and Katarzyna Bebenek. National Library of Medicine, Mar. Image Courtesy: 1. Samanthi Udayangani holds a B. Degree in Plant Science, M. Your email address will not be published. Figure DNA polymerase. Figure DNA Polymerase 1. Figure DNA Polymerase 2. Leave a Reply Cancel reply Your email address will not be published. DNA Polymerase 1 vs 2 vs 3.